Fresh analysis suggests that people who come off blockbuster slimming jabs like Wegovy and Mounjaro tend to recover shed pounds at a significantly accelerated pace than those who end conventional diet and exercise programs.
Published data in a leading medical journal points out that while obese people frequently drop a large proportion of their body weight while using the jabs, the weight returns at an average rate of 0.8 kg per month after stopping.
"Users purchasing these treatments should be aware of the danger of rapid rebound weight gain when the therapy concludes," warns researcher Dr. Susan Jebb.
Such speed of regain means a return to starting weight in about 18 months.
Analyzing Treatments
The research, which examined dozens of studies involving thousands of patients, compared the results of the injectable medications with conventional dieting.
Researchers emphasize that people who lose weight through lifestyle changes alone generally have a slower creep back—perhaps 100 grams monthly—once they finish.
The Reason for the Rapid Regain
Experts propose the way of the jabs explains the amplified regain.
The injections mimic a natural hormone called GLP-1, which moderates feelings of fullness.
"Sustained high doses of GLP-1 concentrations far above than normal may cause the body to produce less of its own natural hormone, and may also reduce sensitivity to its effects," said Dr. Adam Collins, a nutrition specialist.
"Discontinuation of this medication means hunger is unsuppressed, making overeating far more likely."
An Ongoing Disease?
Medical guidelines recommend the injections for people with obesity-related medical conditions, accompanied by prescribed diet and exercise modifications.
A number of clinicians contend that, due to the likelihood of relapse, the therapy is often long-term.
This view is echoed by drug manufacturers, who say that the results "emphasize the chronic character of excess weight," akin to managing conditions like high blood pressure.
Patient Testimonies
Individuals who have stopped the medication describe a sudden resurgence of cravings.
"I experienced something activating and you're instantly ravenous," recalled one woman.
This challenge is worsened if patients have not adopted sustainable lifestyle or habit modifications during therapy.
Widespread Use
Recent estimates indicate that millions of people in the UK have tried weight-loss jabs in the last 12 months, with desire remaining high.
- Use is greater among women compared to males.
- The middle-aged age group shows the greatest usage rates.
- A large proportion obtain the medications through private prescriptions rather than the NHS.
In conclusion, researchers stress that while the jabs are potent agents for weight loss, they are not a standalone cure and long-term success likely depends on ongoing behavioural management.
